Endocrine Abstracts

Introduction: The best repletion and maintenance dosing regimens with cholecalciferol in vitamin D deficient HIV-1 patients remain unknown. Protease inhibitors (PIs) have been shown to inhibit vitamin D 1α- and 25α-hydroxylation in hepatocyte and monocyte cultures. We therefore evaluated the effect of a single high dose of cholecalciferol in vitamin D deficient HIV-1 postmenopausal women undergoing treatment with highly Active Anti-Retroviral Therapy (cART), with and...

Primary hyperparathyroidism (PHPT) is rare in the pediatric population, with an estimated incidence of 0.5–5 cases per 100,000 person-years in children. Data regarding the clinical phenotype, the surgical outcomes are scarce. The objective of our study was to retrospectively analyze the phenotype of apparently sporadic PHPT in patients ≤21 years in major endocrinology reference centers in Italy. None of the patients had known familial syndromes. A total of 41 patien...

Background: Primary hyperparathyroidism (PHPT) is the third most common endocrine disease and the most frequent cause of hypercalcemia in outpatients with an estimated incidence of 20/100 000/year and prevalence in the general population of 0.1%–0.4%. Parathyroidectomy (PTX) is the only treatment that can achieve PHPT cure but a few medications can be used to control calcium levels, bone and kidney impairment.Aims: 1) To assess costs associated with...